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Is Glycation In The Pre-Diabetics Future?

by Douglas Hunt

Glycation in a term used to describe the bonding of a sugar like glucose to a protein or a fat. Sometimes the protein wants to incorporate a sugar molecule into its frame to make it more functional, this it can do enzymatically. This type of bonding is normal and there is another name for it.

Sugars can glycate to proteins in a haphazard fashion. The protein, in this case, does not seek it because the metabolic function of the protein is then severely degraded.

Table sugar is sucrose, it's made up of glucose and fructose. They are divided in the stomach and then absorbed into the blood. Fructose is ten times more able to glycate than glucose.

Sugars are tacky things, the greater the number and the longer the exposure to them the higher the chances of glycation.

Glycations interfere with molecular and cellular functioning throughout the body as well as to throw off highly-oxidizing, toxic, side-products such as hydrogen peroxide.

Glycation severely affects long lived cells in the nerves and brain, long lasting proteins in vital organs as well as DNA. Glycation even attacks beta cells in the pancreas, important because they produce the insulin used to fight glycation. Maybe worst, glycation stiffens as well as weakens blood vessels.

AGEs, advanced glycation end products are what the glycated molecule ends up being, basically it is a toxic waste product. Essentially there are no tissues that are immune to glycation therefore all organs and system are vulnerable to chronic diseases: Alzheimer's, cardiovascular, cancer, neuropathology's, diabetes, eyes, ears, etc, etc.

Red blood cells are easily accessible and therefor can be easily measured for increases in glycating material. Recently it has been determined that the monitoring of the state of diabetes is best done by determining HbA1c. HbA1c is the measurement of glycated hemoglobin levels in the cells.

There are additional pathologies in diabetes beyond glycation, some may be worse, but they are less understood.

As you can see, diabetes is definitely a life shortening disease to be feared. Early diabetes and especially during pre-diabetes one still has time to actively back out of the mess ahead.

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